TB-500 (Thymosin Beta-4 Fragment)
Studied for its ability to promote cell migration and new blood-vessel formation, aiding overall soft-tissue and muscle recovery.
Laboratory and educational research purposes only.What is TB-500?
TB-500 is a synthetic peptide fragment of thymosin beta-4, a naturally occurring protein found in nearly all human and animal cells. It plays a key role in tissue repair, regeneration, and inflammation control. TB-500 has gained popularity in sports medicine and longevity circles for its ability to accelerate healing of soft tissues, support vascular, skin and cardiac repair, and promote cell migration to injury sites.
Mechanism(s) of Action
Actin-binding protein fragment → regulates cell migration and proliferation, critical for wound repair.
Promotes angiogenesis (new blood vessel growth), improving nutrient delivery and healing capacity.
Stimulates stem cell differentiation and recruitment to injury sites.
Reduces inflammation and fibrosis, supporting cleaner, faster recovery.
Enhances keratinocyte and fibroblast activity, key players in skin, tendon, and ligament healing.
Improves endothelial function, aiding vascular and cardiac tissue repair.
1. Accelerates soft tissue repair — speeds recovery of muscles, tendons, and ligaments.
2. Supports tendon-to-bone healing — useful after surgical repair or stubborn injuries.
3. Promotes angiogenesis — improves blood supply to damaged or ischemic tissues.
4. Reduces inflammation & fibrosis — minimizes scar tissue formation.
5. Cardioprotective effects — experimental data suggest protection and repair of heart tissue post-injury.
6. Neuroprotection — may support regeneration of nerves and reduce secondary damage after trauma.
7. Enhances skin and wound healing — accelerates closure and quality of tissue repair.
8. Systemic healing effects — unlike BPC-157 (more localized), TB-500 distributes more widely for broader systemic repair. 9. Stimulates stem-cell recruitment
Summary:
TB-500 is best known as a regenerative peptide that promotes wound healing, angiogenesis, and tissue regeneration across multiple systems. It complements BPC-157, which is stronger for gut and localized tendon healing, while TB-500 tends to have more systemic and vascular effects.