Semax
A nootropic peptide of interest for studies on cognitive performance, memory, and mental clarity under stress.
Laboratory and educational research purposes only.What is Semax?
Semax is a synthetic peptide originally developed in Russia, derived from the adrenocorticotropic hormone (ACTH 4-10 fragment) but modified for stability and activity. It’s classified as a nootropic and neuroprotective agent, widely studied for enhancing cognitive function, neuroplasticity, and recovery from brain injuries. It is used clinically there for stroke recovery, cognitive decline, and optic nerve disorders, and experimentally as a cognitive enhancer.
Mechanism(s) of Action
NNMT inhibition → prevents excessive methylation of nicotinamide, preserving NAD⁺ pools.
NAD⁺ salvage pathway → supports mitochondrial energy production and redox balance.
AMPK activation → increases fat oxidation and insulin sensitivity.
Mitochondrial biogenesis pathways (PGC-1α) → enhances endurance and metabolic resilience.
Influences mTOR/AMPK balance, mimicking exercise-like effects.
1. Cognitive enhancement — improves focus, attention, and memory.
2. Neuroprotection — protects neurons against hypoxia, ischemia, and oxidative stress.
3. Stroke recovery support — shown in Russian clinical use to improve outcomes after ischemic stroke.
4. Mood stabilization — supports serotonin/dopamine balance; may reduce anxiety and depression.
5. Vision support — used for optic nerve disorders and retinal degeneration.
6. Anti-fatigue effect — improves resilience to mental and physical stress.
7. Potential neuroplasticity enhancer — boosts learning and adaptability through BDNF.
Summary:
Semax is primarily valued as a neuroprotective and nootropic peptide, enhancing BDNF, neurotransmitter balance, and brain plasticity. It has strong data for stroke recovery, cognitive enhancement, and mood regulation, with minimal side effects.
