PT-141
Studied for its potential to enhance sexual desire and arousal through central nervous system pathways.
Laboratory and educational research purposes only.What is PT-141?
PT-141 is a synthetic peptide derived from Melanotan II, designed specifically for sexual dysfunction treatment. Unlike PDE5 inhibitors (e.g., Viagra), which act on blood vessels, PT-141 works through the central nervous system, directly activating pathways that influence sexual desire and arousal. It is FDA-approved for treating hypoactive sexual desire disorder (HSDD) in premenopausal women, but is also widely used off-label in men for erectile dysfunction and libido enhancement.
Mechanism(s) of Action
Melanocortin receptor activation (MC3R & MC4R): Stimulates central melanocortin pathways in the hypothalamus that regulate sexual arousal.
CNS pathway modulation: Increases dopamine release and excitatory signaling in brain regions associated with desire.
Indirect vascular effects: Unlike PDE5 inhibitors, it does not directly vasodilate but may enhance erectile function through neural stimulation.
Pathway distinct from nitric oxide (NO) signaling — useful for patients unresponsive to PDE5 inhibitors.
1. Increases sexual desire — enhances libido in both men and women.
2. Improves arousal and satisfaction — strengthens sexual response and orgasm quality.
3. Treats ED (erectile dysfunction) — effective in men who don’t respond to PDE5 inhibitors.
4. Effective in HSDD (low libido disorder) — FDA-approved for women with this condition.
5. Works centrally — activates arousal pathways in the brain rather than relying only on blood flow.
6. Rapid onset — typically effective within 30–60 minutes of administration.
7. May improve mood and bonding — melanocortin system overlaps with mood-regulating circuits.
Summary:
PT-141 is a libido-enhancing peptide that works via melanocortin receptor activation in the brain, making it effective for sexual desire and arousal issues in both men and women. Unlike Viagra, it works on neural arousal pathways rather than just circulation, offering benefits in cases resistant to traditional ED drugs.