PEG-MGF
Explored for its role in muscle repair and adaptation following exercise by activating satellite cells and growth factors.
Laboratory and educational research purposes only.What is PEG-MGF?
PEG-MGF is a pegylated (stabilized) form of Mechano Growth Factor (MGF), an IGF-1 splice variant released in muscle following mechanical stress or injury. Natural MGF has a very short half-life, but pegylation extends its activity, allowing for systemic effects. It is primarily used for muscle repair, hypertrophy, and recovery, making it a key peptide in performance and rehabilitation contexts.
Mechanism(s) of Action
IGF-1 splice variant activation: Stimulates satellite cell proliferation and differentiation in skeletal muscle.
mTOR/PI3K-Akt pathway: Promotes protein synthesis and muscle hypertrophy.
Muscle repair signaling: Enhances regeneration of damaged fibers.
Angiogenesis induction (VEGF upregulation): Improves blood supply to muscle tissue.
Stem cell activation: Recruits myogenic stem cells to injury sites for tissue repair.
1. Stimulates muscle growth — increases muscle fiber size via satellite cell activation.
2. Accelerates recovery — improves repair after intense training or injury.
3. Supports hypertrophy — works synergistically with IGF-1 LR3 for muscle development.
4. Improves endurance capacity — supports angiogenesis and oxygen delivery.
5. Prevents muscle wasting — counteracts catabolism from overtraining or illness.
6. Localized repair — when injected near injury sites, enhances targeted regeneration.
7. Extended activity — pegylation prolongs half-life, improving systemic effects.
Summary:
PEG-MGF is a stabilized muscle-repair peptide that extends the natural effects of mechano growth factor, promoting hypertrophy, recovery, and injury repair through satellite cell activation and IGF-1–related pathways.