Kisspeptin
Examined for its role in reproductive hormone signaling, Kisspeptin is studied for potential impacts on fertility and hormonal health.
Laboratory and educational research purposes only.What is Kisspeptin?
Kisspeptin is a naturally occurring neuropeptide encoded by the KISS1 gene. It was first identified as a metastasis suppressor, but later discovered to be a master regulator of reproduction. Kisspeptin plays a crucial role in triggering the release of GnRH (gonadotropin-releasing hormone), thereby controlling puberty, fertility, and sex hormone production.
Mechanism(s) of Action
Kisspeptin receptor (KISS1R/GPR54) activation → binds to its GPCR receptor in the hypothalamus.
Stimulates GnRH neurons → activates the hypothalamic–pituitary–gonadal (HPG) axis.
Leads to release of LH and FSH from the pituitary → stimulates testosterone, estrogen, and progesterone production.
Involved in puberty initiation pathway and fertility signaling cascade.
Has roles in tumor suppression and placental development.
1. Fertility support — stimulates GnRH → LH/FSH → improves ovulation in women and spermatogenesis in men.
2. Puberty induction — key trigger for the onset of puberty in adolescents.
3. Testosterone boost in men — increases LH secretion, which stimulates testicular testosterone production.
4. Female reproductive health — regulates menstrual cycles, follicle maturation, and may aid IVF protocols.
5. Pregnancy support — important in placental development and maintaining pregnancy.
6. Metastasis suppression — original role of KISS1 gene, limiting cancer spread.
7. Mood & libido regulation — via hypothalamic signaling (still under study).
Summary:
Kisspeptin is a master regulator of the reproductive axis, driving GnRH release and subsequent sex hormone production. Its primary uses are in fertility, puberty disorders, and reproductive endocrinology, with added interest in cancer suppression and pregnancy health.