Follistatin 344
A naturally occurring protein studied for its potential to encourage lean muscle development by influencing myostatin activity, Follistatin-344 is often examined in the context of strength and body-composition research.
Laboratory and educational research purposes only.What is Follistatin 344?
Follistatin 344 is a synthetic version of follistatin, a natural glycoprotein found in human tissues. It is best known for its ability to inhibit myostatin, a protein that restricts muscle growth. By blocking myostatin and related TGF-β family proteins, Follistatin 344 has become a target in muscle growth, performance, and regenerative medicine research.
Mechanism(s) of Action
Myostatin inhibition → directly suppresses myostatin activity, removing its “brake” on muscle growth.
Activin inhibition → modulates activin-related signaling, impacting muscle, inflammation, and reproductive hormone pathways.
TGF-β superfamily modulation → influences cell growth, differentiation, and fibrosis.
Enhances satellite cell activation → supports muscle regeneration and hypertrophy.
1. Increases muscle growth — promotes hypertrophy beyond natural genetic limits.
2. Improves strength & performance — greater muscle mass leads to functional gains.
3. Supports recovery & regeneration — enhances satellite cell activity and muscle repair.
4. Reduces fibrosis — limits scar tissue in muscle and organ tissue.
5. Potential metabolic benefits — may improve insulin sensitivity and reduce fat mass (still under research).
6. Longevity/anti-aging interest — studied for sarcopenia (age-related muscle loss).
Summary:
Follistatin 344 is mainly valued for dramatic muscle growth and regeneration by blocking myostatin, but its side effect profile and long-term safety are not well defined. It shows promise in performance enhancement and anti-aging (sarcopenia) but remains experimental.