DSIP
DSIP is explored for its ability to promote deep, restorative sleep and help regulate circadian rhythms, making it of interest in research on stress balance and nighttime recovery.
Laboratory and educational research purposes only.What is DSIP?
DSIP is a naturally occurring neuropeptide first discovered in the 1970s, named for its ability to promote slow-wave (deep) sleep. It is also involved in stress modulation, endocrine regulation, and neuroprotection. DSIP is typically administered as a peptide supplement (injected or intranasal) in research or longevity settings.
Mechanism(s) of Action
Modulates activity of the GABAergic system and influences sleep-wake cycles.
Regulates secretion of several hormones, including growth hormone (GH), luteinizing hormone (LH), and ACTH.
Enhances stress adaptation by modulating the hypothalamic–pituitary–adrenal (HPA) axis.
Provides neuroprotection by reducing oxidative stress and supporting mitochondrial function.
May act as an anticonvulsant, stabilizing neuronal excitability.
1. Improves sleep quality — promotes slow-wave (deep, restorative) sleep.
2. Reduces sleep latency — helps with falling asleep faster.
3. Supports stress resilience — balances cortisol and stress hormone response.
4. May reduce anxiety — via GABA and serotonin modulation.
5. Enhances recovery — through GH secretion support and improved sleep cycles.
6. Neuroprotection — may protect neurons from oxidative stress and excitotoxicity.
7. Potential anticonvulsant effects — studied for seizure threshold stabilization.
Summary:
DSIP is mainly valued for deep sleep promotion, stress regulation, and neuroprotection. While promising, most data is preliminary, and side effects are generally mild but under-researched for long-term use.