GHK-CU (Copper)
Well known in dermatologic research, GHK-Cu is studied for skin rejuvenation, collagen support, and hair-follicle health thanks to its copper-binding antioxidant properties
Laboratory and educational research purposes only.What is GHK-CU?
GHK-Cu (Glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding peptide found in plasma, saliva, and urine. It has been widely studied for its regenerative, cosmetic, and therapeutic properties.
Mechanism(s) of Action
Copper delivery → transports copper into cells, essential for enzymatic activity in tissue repair and antioxidant defense.
Collagen & ECM remodeling → stimulates synthesis of collagen, elastin, glycosaminoglycans, and decorin.
Stem cell activation → enhances regenerative signaling and wound healing.
Anti-inflammatory & antioxidant → reduces oxidative stress, cytokines, and fibrosis.
Gene modulation → influences thousands of human genes, many tied to anti-aging, antioxidant, and regenerative pathways.
Angiogenesis support → promotes blood vessel growth and tissue oxygenation.
1.Skin & Cosmetic Benefits: Enhances collagen and elastin production, improving skin firmness and reducing wrinkles. Stimulates glycosaminoglycan synthesis, increasing skin hydration and elasticity. Promotes wound healing and reduces scarring.
2. Hair Growth: Stimulates hair follicle activity, prolongs the growth (anagen) phase, and increases follicle size. Improves scalp blood flow and follicle nutrient delivery.
3. Tissue Repair & Regeneration: Accelerates healing of wounds, ulcers, and surgical sites. Promotes regeneration of nerves, blood vessels, and other connective tissues.
4. Anti-Inflammatory & Antioxidant Effects: Reduces oxidative stress by acting as a copper-dependent antioxidant. Lowers inflammatory cytokines, supporting systemic healing.
5. Neurological & Systemic Support: Shows potential for repairing nerve damage. May improve cognitive function by supporting neuronal growth and reducing oxidative injury.
Human Data: Clinical studies demonstrate improved wound healing, skin rejuvenation, reduction of fine lines and wrinkles, and stimulation of hair regrowth. Some systemic applications remain experimental but are supported by gene expression studies showing activation of regenerative pathways.
Summary:
GHK-Cu is a multifunctional peptide that delivers copper to tissues, supporting collagen production, wound healing, hair growth, and systemic regeneration. Its benefits extend to anti-aging, skin health, tissue repair, and potential neurological protection.