CJC- 1295 (no DAC) + Ipamorelin blend
This combination is under study for stimulating natural growth hormone release, supporting recovery, and maintaining healthy body composition.
Laboratory and educational research purposes only.What is CJC- 1295 (no DAC) + Ipamorelin blend ?
CJC-1295 is a growth hormone–releasing hormone (GHRH) analog that stimulates the pituitary to release GH. Ipamorelin is a ghrelin mimetic and growth hormone secretagogue receptor (GHSR) agonist that also stimulates GH release without significantly affecting cortisol or prolactin. The combination provides a stronger and more sustained GH pulse, leading to increased IGF-1 levels that drive many regenerative and anti-aging effects.
Mechanism(s) of Action
CJC-1295 (GHRH analog): Activates GHRH receptors on pituitary somatotrophs → increases amplitude of GH pulses.
Ipamorelin (Ghrelin mimetic): Binds GHSR (ghrelin receptor) → triggers GH release via calcium and cAMP/PKA signaling.
GH → IGF-1 axis (JAK/STAT pathway): GH stimulates liver and tissues to produce IGF-1, driving anabolic effects.
Metabolic pathways: Shifts balance toward lipolysis (fat burning) and lean tissue preservation.
For Anti-Aging:
1.Cellular & Anti-Aging Effects: Increases GH and IGF-1, supporting cellular repair, mitochondrial health, and protein synthesis. Enhances recovery from tissue damage and improves overall vitality. May improve sleep quality by restoring circadian GH secretion.
2.Body Composition & Metabolic Health: Promotes lean muscle growth and helps reduce body fat. Improves lipid metabolism and insulin sensitivity. Supports more youthful energy balance and metabolism.
3.Skin & Connective Tissue: May improve skin elasticity and thickness through IGF-1–driven collagen synthesis. Supports joint health and connective tissue integrity.
4.Neurological & Cognitive Support: GH and IGF-1 have neuroprotective roles, potentially supporting memory, learning, and brain health. May improve mood and sense of well-being.
5.Immune & Recovery Benefits: Enhances tissue healing and recovery from injuries. Supports immune resilience by stimulating regenerative pathways.
-Human Data: Clinical studies on CJC-1295 demonstrate increased GH and IGF-1 levels with improved metabolic and body composition markers. Ipamorelin is shown to increase GH without significant side effects.
Summary: CJC-1295 and Ipamorelin together increase GH and IGF-1 levels, which support anti-aging effects such as improved body composition, recovery, skin health, and cognitive resilience."
For Body Composition:
1. Fat Loss — GH promotes lipolysis, especially mobilizing visceral and subcutaneous fat stores, leading to lower body fat percentage.
2. Muscle Preservation & Growth — IGF-1 supports muscle protein synthesis and tissue repair, helping preserve or build lean mass during fat loss.
3.Improved Nutrient Partitioning — Shifts metabolism toward using fat for energy while sparing glycogen and amino acids.
4. Enhanced Recovery — Faster recovery from training allows higher training volume/intensity, indirectly improving muscle gain and fat loss.
5. Improved Sleep & GH Pulsatility — Better deep sleep increases natural GH release, indirectly aiding fat reduction and muscle repair.
6. Skin & Connective Tissue Quality — Collagen synthesis support helps maintain skin elasticity and joint/tendon integrity, indirectly improving training capacity.
Summary:
CJC-1295 + Ipamorelin doesn’t act like a steroid (direct anabolic) — instead, it gradually reshapes body composition by reducing fat mass and maintaining or modestly increasing lean mass. Most changes are subtle and cumulative over months, especially when paired with diet and training.