BPC-157
A gastric peptide fragment under investigation for supporting tissue repair, gut integrity, and recovery from musculoskeletal injury.
Laboratory and educational research purposes only.What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protective protein found in human gastric juice. It is best known for its tissue-healing, anti-inflammatory, and cytoprotective properties. Unlike many peptides, it works across multiple systems (musculoskeletal, vascular, gut, nervous system) and has shown strong regenerative effects in animal studies.
Mechanism(s) of Action
Stimulates angiogenesis by upregulating VEGF and other growth factors → enhances blood vessel formation and nutrient delivery to damaged tissue.
Promotes fibroblast and collagen synthesis → accelerates tendon, ligament, muscle, and bone repair.
Protects endothelial lining and maintains microvascular integrity, reducing tissue ischemia.
Enhances nitric oxide (NO) signaling, improving circulation and exerting anti-inflammatory effects.
Modulates dopamine and serotonin pathways, suggesting neurological and mood benefits.
Gastroprotective via increased prostaglandin and growth factor activity, shielding gut mucosa from damage.
1. Accelerated soft tissue healing — speeds repair of tendons, ligaments, and muscle fibers.
2. Supports bone and joint repair — enhances tendon-to-bone healing, reduces recovery time from injuries and surgeries.
3. Gut protection & healing — shown to heal ulcers, protect against NSAID damage, and support liver function.
4. Anti-inflammatory effects — reduces swelling, oxidative stress, and pain at injury sites.
5. Neuroprotection — supports peripheral nerve regeneration and protects neurons after trauma.
6. Cardiovascular protection — preserves microvascular function, protects blood vessels from stress and ischemia.
7. Improved circulation & angiogenesis — enhances blood supply to healing tissue, supporting regeneration.
8. Possible mood & CNS benefits — animal models suggest anti-depressive and anxiolytic effects.
Summary:
BPC-157 is one of the most versatile regenerative peptides, with strong effects on musculoskeletal repair, gut integrity, vascular health, and neurological protection. While most evidence comes from preclinical (animal) research, it has become widely used in the performance, longevity, and recovery space for its broad healing profile.