AOD 9604
A fragment of growth hormone being researched for its ability to promote fat breakdown and support healthy body composition.
Laboratory and educational research purposes only.What is AOD 9604?
AOD-9604 is a synthetic peptide fragment of human growth hormone (HGH), specifically amino acids 176–191 of the GH molecule. Unlike HGH, it does not stimulate IGF-1 or cause growth-related side effects, but it retains the fat metabolism properties of GH. It was originally developed as an anti-obesity drug and is now studied as a fat-loss and metabolic support peptide.
Mechanism(s) of Action
Selectively activates the lipolytic (fat-burning) pathway of HGH without activating IGF1.
Increases cAMP activity in fat cells → enhances lipolysis (fat breakdown).
Inhibits lipogenesis (formation of new fat).
Works primarily on adipose tissue metabolism pathways.
Does not activate JAK/STAT or growth pathways linked to HGH’s anabolic effects.
1. Fat loss support — enhances fat burning, especially in stubborn areas.
2. Prevents new fat formation — reduces lipogenesis.
3. Safe metabolic profile — does not raise IGF-1, avoiding risks of HGH (organ growth, cancer concerns).
4. Joint and cartilage repair — some evidence of benefit for osteoarthritis and joint inflammation.
5. Improved lipid metabolism — may support healthier cholesterol and triglyceride levels.
6. Potential anti-inflammatory effects — early research suggests tissue healing support.
Summary:
AOD-9604 is a HGH fragment peptide that promotes fat burning and prevents fat storage without the anabolic/IGF-1 effects of HGH. It shows promise as a safe fat-loss aid with added joint-repair potential, though large-scale human data is still limited.
