5 - Amino 1MQ
Investigated for its influence on cellular metabolism and energy balance, with early studies exploring links to fat-loss mechanisms.
Laboratory and educational research purposes only.What is 5-Amino?
5-Amino-1MQ is a small molecule peptide-like compound that functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). By blocking NNMT, it helps preserve intracellular NAD⁺ levels, boosting energy metabolism and mitochondrial function. It is often described as a metabolic optimization and fat-loss agent, with growing interest in longevity, obesity, and exercise performance.
Mechanism(s) of Action
NNMT inhibition → prevents excessive methylation of nicotinamide, preserving NAD⁺ pools.
NAD⁺ salvage pathway → supports mitochondrial energy production and redox balance.
AMPK activation → increases fat oxidation and insulin sensitivity.
Mitochondrial biogenesis pathways (PGC-1α) → enhances endurance and metabolic resilience.
Influences mTOR/AMPK balance, mimicking exercise-like effects.
1. Fat loss support — promotes lipolysis and reduces adipose tissue accumulation.
2. Improved insulin sensitivity — enhances glucose control and metabolic health.
3. NAD⁺ preservation — supports mitochondrial health, energy, and longevity pathways.
4. Exercise mimetic effect — increases endurance and physical performance (animal studies).
5. Cardiometabolic health — reduces cholesterol and improves vascular function.
6. Neuroprotection — NAD⁺-boosting effects may protect against age-related cognitive decline.
7. Anti-aging potential — combats cellular senescence by supporting mitochondrial efficiency.
8. Synergistic with NAD+ precursors (NMN, NR) — boosts their effectiveness by reducing NAD⁺ breakdown.
Summary:
5-Amino-1MQ is a metabolic and longevity enhancer that works by inhibiting NNMT, preserving NAD⁺ levels, and activating AMPK/PGC-1α pathways. Benefits include fat loss, insulin sensitivity, mitochondrial health, and exercise-mimetic effects, though human trials are still limited.